Cytokines Therapy for Alopecia

AesMed’s Cytokines Therapy

Discovery and History

Cytokine is a term that refers to various signal factors that act on the cell cycle, such as cell proliferation, growth, differentiation, and self-destruction. If an animal was injured, it had been treated naturally over a period of time, and the EGF (Epidermal Growth Factor) found in observing this phenomenon is the first cytokine (growth factor). Dr. Stanley Cohen, who discovered the EGF in 1962, won the Nobel Prize in Physiology or Medicine in 1986.
In addition to EGF, various growth factors such as bFGF and IGF-1 were discovered, and in addition to growth factors, various signal factors such as IL, BMP, and Noggin were found, and were collectively referred to as cytokines.
As the commercial production of cytokines has become active in the 2000s, the number of practical cytokines has increased to dozens and the field of medical use is expanding.


The names of cytokines are usually named to reflect typical characteristics, but they do not necessarily coincide with their names. For example, EGF is named Epidermal Growth Factor, but it is also an essential growth factor for dermal growth of dermal cells.

• Cytokines does not directly penetrate into cells but works primarily by combining with receptors in cell walls to transmit certain signals to cell DNA. Therefore, cytokines have a great effect in trace amounts.
• The same type of cytokine can grow and regress cells depending on the area and mechanism. EGF, for example, has a growth effect on normal skin cells, a degenerative effect on hair follicle cells, TGF-β1, TGF-β2 has a cell degenerative effect, and TGF-β3 has a cell growth effect.
• One cytokine may lead to the occurrence of another cytokine, and when several cytokines are used together, synergies may be used, and vice versa. For example, EGF+bFGF has a synergistic effect and BMP+Noggin has an antagonism.
• Cytokine can be identified by grouping similar species into family. For example, FGF Family: FGF1=aFGF, FGF2=bFGF, FGF7=KGF.
• Cytokines is still about the complex signaling systems of human bodies that are far more unknown than humans know, so it should only utilize cytokines that have been scientifically verified. Even when a combination of various cytokines is made, only the identified characteristics must be used.

What about good cytokines?

Cytokine is mainly produced with the technique of gene recombinant. Although it is sometimes produced by synthesizing a bio-micro-peptide, it is difficult to function as cytokine in this case. Cytokine produced by gene recombination technology is protein-like and must be thoroughly sterilized, frozen, and vacuum stored. Liquid cytokines will lose their function in just a few months. There are also products of nanoscale cytokine, but with current nanoscale technology, it is difficult to maintain the original function of cytokine. Because cytokines must be produced individually and remain active, a stabilization process must be performed. Cytokine, which is contained in stem cell culture fluid or PRP, is not produced individually, so it is difficult to maintain its vitality for a long time, and the volume of cytokines that it contains is not much.
Most importantly, the technology of a company that has developed the same technology for the longest time. AesMed has been producing products of the same technology for more than 15 years.

Growth factor FGF signal
Growth factor FGF signal

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Seven key growth factors used in AesMed's Cytokine therapy
kind function image
FGF9 (Fibroblast Growth Factor 9) FGF9 secreted from γδT cells induces an amplification feedback loop resulting in widespread wound dermal Wnt activation necessary for hair follicle regeneration in wounds. FGF9
KGF (Keratinocyte Growth Factor) Keratinocyte growth and differentiation control, New hair formation control, Keratinocyte protect from UVA/B or chemotherapy, cell damage prevention and hair survival KGF
IGF-1 (Insulin-like Growth Factor) Acts as a Growth Hormone, Angiogenesis, Keratinocyte proliferation stimulation and hair follicle growth control and anagen maintenance. IGF-1
VEGF (Vascular Endothelial Growth Factor) Angiogenesis formation stimulation and blood vessel maintenance. Hair vessel size and numbers augmentation. VEGF
bFGF (basic Fibroblast Growth Factor) Collagen and Elastin stimulation, hair growth stimulation and follicular dermal papilla activation. bFGF
Noggin (BMP antagonist) BMP signal inhibition, DKK-1 inhibition and Wnt signal activation, New hair follicle formation and anagen inducer Noggin
Cu/Zn SOD (Superoxide Dismutase) Hair follicle protection from oxidation stress and hair growth stimulation Cu/Zn SOD

Follicular cell Cytokines

(6 Growth Factors+SOD) : KGF, FGF9, IGF-1, bFGF, VEGF, Noggin & SOD-1

Multi-nutrition component

(Multi-nutrients): 37 nutrients needed for energy metabolism of hair follicle cells